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2022 Mercedes-Benz E-Class Trim Levels, Configurations & Comparisons.

2022 Mercedes-Benz E-Class Trim Levels, Configurations & Comparisons: 350 vs 350 4MATIC vs 450 4MATIC

What 2022 Mercedes-Benz E-Class Trim Should You Buy? What is the Difference Between Trims?

Available in three trim levels, the 2022 Mercedes-Benz E-Class is an executive sedan with lots of upscale amenities and sophisticated technologies. Under the hood, this premium German car offers a turbocharged powertrain, 9G-TRONIC automatic transmission and lots of other exclusively engineering wonders. An air suspension system certainly optimizes the capabilities of this luxury sedan without sacrificing comfort.

From climate-controlled front seats with massaging settings to a heated steering wheel, the 2022 MB E-Class offers lots of high-end amenities for year-round comfort. Genuine leather upholstery and real wooden accents add elegant appeal to the cabin. This lavish MB sedan also comes in alluring body colors, such as Cardinal Red and Nautical Blue. AMG-style wheels with multiple spokes and black accents are available for this premium sedan that's manufactured by a legendary European auto brand.


Compare the 2022 Mercedes-Benz E 350 vs E 350 4MATIC. What is the Difference?

Whipping out a total of 255 net horsepower, a 2.0-liter engine block is standard under the hood of the 2022 Mercedes-Benz E 350 base trim. Using rapid multi-spark ignition and direct injection, the four-cylinder powertrain unleashes 273 pound-feet of maximum torque. A twin-scroll turbocharger optimizes the combustion cycles in this I-4 powerplant. Additionally, the proprietary CAMTRONIC mechanical technology lifts the valves.

Equipped with a rear-wheel drive (RWD) system, the entry-level model accelerates from 0 to 60 mph in just 6.1 seconds. All power flows from the 9G-TRONIC automatic transmission system to the rear driveline. According to EPA projections, this luxurious Mercedes-Benz sedan delivers up to 31 mpg on the highway and 23 mpg in the city. Illuminated by a green indicator light on the center console, the ECO Start/Stop button optimizes the fuel economy in various driving conditions. When the driver lifts the foot from the brake pedal, the twin-turbo engine immediately restarts itself.

Controlled by a metallic switch on the center console, the DYNAMIC SELECT technology calibrates several mechanical systems in real time. For instance, the Sport+ Mode significantly improves the response from the throttle system and gearbox for aggressive handling on the road. The COMFORT Mode softens the steering system and shifting points for a smooth ride on any paved surface. When the ECO Mode comes on, the vehicle achieves peak fuel efficiency on the highway or in the city. Additionally, the Individual Mode enables manual-style shifting.

Riding on a four-wheel, multi-link suspension system, the 2022 Mercedes-Benz E 350 maintains great poise on the road. Forged-aluminum components provide a great balance of resilience and toughness on this premium MB sedan. By lowering the suspension system, the Selective Damping System optimizes aerodynamics and overall handling at various speeds. With leverage from the Dynamic Cornering Assist, this luxurious car carves through corners with ease. An electromechanical power steering system enables swift and nimble handling on the streets and freeways.

The 2022 MB E-Class base edition is available with the optional AIR BODY CONTROL, which precisely adjusts the shock absorbers and other components for a dynamic and comfortable drive. For instance, the suspension system becomes more stiff when enhanced cornering is required. Using a simple switch, the driver could manually adjust the stiffness of this advanced air suspension system. Featuring an array of perforations for maximum dissipation of heat, the Sport Brake System is optional on the entry-level trim.

When it comes to ergonomics, the 2022 Mercedes-Benz E 350 boasts an array of premium interior amenities. This executive-style sedan comes standard with a power-adjustable driver's seat that's linked to a three-position memory system. With the press of a button, it's also possible to instantly adjust the four-way steering wheel into a desirable position. Of course, a four-way lumbar support reduces fatigue for an extended drive in this lavish vehicle. Having a 40-20-40 configuration, the split-folding rear seats deliver a high level of utility and comfort.

Featuring three-step heating, the front and rear seats inside the 2022 Mercedes-Benz E 350 are available with premium leather upholstery. Heating is even available for the armrests in the first row of this lavish sedan. Three levels of ventilation are optional for the ergonomic seats in the front row. A power sunshade fully covers the rear window for enhanced comfort on hot days. Additionally, this executive MB sedan comes standard with a dual-zone automatic climate control system that includes a high-capacity pollen filter.

The driver could illuminate the 2022 Mercedes-Benz E 350 in one of 64 unique colors from the ambient lighting system. It's even possible to adjust the brightness of each glow for a truly personalized aura inside the cockpit. The powerful ambient lighting system illuminates the footwells, dashboard, interior door handles and other parts of the deluxe cabin. An illuminated entry system surely provides a warm welcome for the driver at night. This unique lighting technology is fully synced with the programmed KEYLESS-GO fob, which also controls the KEYLESS-START function.

Available on the 2022 E-Class base edition, the Active Multicontour front seats elevate the ergonomics to unprecedented levels. These advanced seats include active side bolsters that automatically respond to any cornering and other lateral motion. Up to eight massage options are at the driver's fingertips for the ultimate comfort during any drive. Two of the custom settings mimic the soothing effects of hot stone massages from upscale spas. Advanced head restraints and rapid heating are some other major highlights of the Active Multicontour seats.

When it comes electronic technology, the 2022 Mercedes-Benz E 350 is loaded with an assortment of impressive items. This executive sedan comes standard with a 12.3-inch center display that recognizes the slightest touch and an array of voice commands. The exclusive Touch Control interface on the steering wheel provides an alternative way for accessing the MB User Experience platform. Predictive features also deliver an extra level of convenience for managing the infotainment console inside this luxury MB sedan.

Also having a field of vision of 12.3 inches, a digital instrument cluster is standard on the E-Class base model. Some custom display modes include the Progressive and Sport. Scrolling through the menu will be easy with the unique Touch Control technology that's at the driver's fingertips. Likewise, the advanced Touchpad Controller instantly engages the MBUX software during a drive. This hardware also comes with virtual keys that provide direct shortcuts to the home menu and other widgets on the infotainment system.

Importing mobile applications into the MBUX console will be easy through the Android Auto and Apple CarPlay portals. Similarly, Bluetooth is already integrated into the car's sophisticated infotainment suite. USB-C ports in the first row enable convenient plug-and-play connections with compatible mobile devices. The E-Class base trim is also available with an optional Wi-Fi modem and inductive charging for smartphones. Additionally, near field communication (NFC) is available for syncing certain mobile devices.

Having an 8.0-inch wide footprint, a color head-up display is optional for the 2022 Mercedes-Benz E 350. With visual cues from the optional MBUX Augmented Video for Navigation, the driver will easily follow directions in real time. The MBUX Interior Assistant delivers superb guidance for any type of drive or task. This exclusive function is easily activated with a simple wave of the hands in front of the dashboard. The virtual assistant recognizes unique gestures from the driver and front occupant for a fast response.

Standard inside the entry-level E-Class model, the FrontBass System optimizes acoustics from HD Radio, SiriusXM Satellite Radio and other sources. A one-year subscription to Live Traffic Traffic information supplements the default audio system. This upscale MB sedan may be equipped with the upgraded Burmester Surround Sound System, which has a total of 13 high-quality speakers. Featuring aluminum grilles, the powerful speakers emit crisp and pleasant output throughout the elegant cabin.

As a luxury sedan, the 2022 Mercedes-Benz E 350 is naturally packed with a wide assortment of active safety technologies. This vehicle includes the standard ATTENTION ASSIST that analyzes 70 unique metrics in real time. When a frontal impact is imminent, the Active Brake Assist will come on. When another car enters the driver's blind zone, the Blind Spot Assist will issue the appropriate alerts. Driving on a windy day won't be a major issue because this luxury sedan has the standard Crosswind Assist technology.

Equipped with the standard Parking Damage Detector, the 2022 E-Class base model offers peace of mind for urban drivers. This lavish sedan also has the Rearview Camera System that records wide views of whatever is behind the trunk. When dealing with an emergency on the road, the driver could use the default Mercedes-Benz Emergency Call Service, which is activated by a red SOS button. Additionally, the Car-to-X Communication continuously monitors the surroundings for any detectable hazards.

Fitted with seven air bags, the 2022 E 350 offers superb value in passive safety. These advanced air bags deliver nine-way protection against a wide range of typical crashes and other incidents on the road, including rollovers. Thanks to the trademark PRE-SAFE SOUND technology, the driver and occupants will be protected from any loud noises that could damage the ears during a crash. This unique technology emits special acoustics that neutralize the harshness of noise from shattered glass.

More than a dozen other sophisticated safety features are optional on the 2022 E 350, such as the Evasive Steering Assist and Congestion Emergency Braking. Driving on busy highways with variable speed limits will be easier with cues from the Active Speed Limit Assist and Route-Based Speed Adaption. This lavish MB sedan also offers the PARKTRONIC technology with automatic steering adjustments. Additionally, the Surround View System provides clear views of the car's entire perimeter.

When it comes to engineering, the 2022 Mercedes-Benz E 350 4MATIC distinguishes itself with a 4WD system. By optimizing the torque flow to each wheel, this advanced drivetrain delivers safe and consistent handling in any weather conditions. Featuring sensors that monitor torque and other metrics in real time, the Electronic Stability Program works in sync with the exclusive 4MATIC drivetrain. Additional support is provided by the 4-Wheel Electronic Traction System (4-ETS) based on the driving conditions.

When it comes to fuel efficiency, the E 350 4MATIC has slightly lower ratings than the base model. This upgraded edition gets up to 21 mpg in the city and 29 mpg on the highway. Accelerating from 0 to 60 mph in 6 seconds, the model with the 4WD system is slightly faster by a fraction of a second. Otherwise, the performance dynamics are nearly identical for both sedans.

Compare the 2022 Mercedes-Benz E 350 4MATIC vs E 450 4MATIC. What is the Difference?

The 2022 Mercedes-Benz E 450 4MATIC is equipped with a 3.0-liter engine block that kicks out a maximum of 369 net horsepower. Having an inline-six configuration, this turbocharged powertrain is much more capable than the 2.0-L turbo engine on the E 350 4MATIC edition. Boosted by a mild-hybrid system, the I-6 powerplant cranks out a total of 362 lb-ft of peak torque. In some driving situations, the six-cylinder engine enables cruising and coasting without burning a single drop of gasoline.

Rolling on the 4MATIC drivetrain, the E 450 model accelerates from 0 to 60 mph in only 4.9 seconds. Such rapid acceleration is enabled by the instant delivery of torque from the mild-hybrid powertrain. Fuel economy ratings for this efficient propulsion system include 23 mpg in the city and 30 mpg on the highway.

The 2022 E 350 4MATIC and E 450 4MATIC both offer an optional dashcam for enhanced security on the road. Capturing high-resolution videos at a high frame rate, this camera faces the car's projected path. This advanced optical system also records the vehicle's speed. All videos could be easily reviewed on the multimedia display in the center stack.

Buying Tip:

To avoid overpaying on a new car, shop prices online first. Get up front pricing before you walk into a dealership. We recommend the following free services; Car Clearance Deals, NADAguides, CarsDirect & Motortrend.
These free services will offer you the lowest prices and supply you with multiple competing price quotes. You will know the best price before you visit the dealer.

Which Trim to Choose?

Having a mid-level position on the 2022 Mercedes E-Class lineup, the E 350 4MATIC is a solid choice for American consumers seeking high-end luxury and sporty performance. Equipped with an advanced 4WD system, the E 350 4MATIC offers better overall handling than the base trim. A twin-turbocharged engine block also delivers lots of horsepower and torque for a thrilling drive. Upgrading to the more expensive E 450 4MATIC certainly comes with access to much more output from a turbocharged I-6 engine. However, the E 350 4MATIC still offers great value in performance for daily drives and long-distance trips.

In terms of safety technologies, all 2022 E-Class models offer the same options for extra peace of mind. All trims also offer superb value in passive safety thanks to seven air bags, PRE-SAFE and high-strength steel framing. Overall, the 2022 E 350 4MATIC edition is a solid choice for discerning drivers on the luxury market.

Compare trims on other Mercedes-Benz Models:

2022 Mercedes A-Class

2022 Mercedes E-Class

2022 Mercedes GLA

2022 Mercedes GLC

2022 Mercedes GLE
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